Checkpoint Inhibitors Side Effects

Common side effects associated with currently approved checkpoint immunotherapies may include but are not limited to.

Checkpoint inhibitors side effects.

On average symptoms appear around nine weeks after starting treatment and may include. He says he figures these are just normal side effects of his medication. Other immune checkpoint inhibitors are under clinical evaluation. Checkpoint inhibitor associated neurological side effects are rare but potentially life threatening.

Mp inflammatory reactions involving the skin and the gastrointestinal tract are among the most common adverse events seen with checkpoint inhibitors. Occasional any grade toxicities in 5 20 of patients include fatigue headache arthralgia rash pruritus pneumonitis diarrhoea and or colitis hepatitis and endocrinopathies table 1. The most common side effects of checkpoint inhibitors are. Fatigue rash colitis infusion related reactions diarrhea asthenia arthralgias constipation decreased appetite cough dyspnea headache insomnia nausea pain including in the abdomen back and musculoskeletal system peripheral edema pneumonitis radiation pneumonitis pruritus pyrexia vomiting and weight loss.

However immune checkpoint blockade can lead to the breaking of immune self tolerance thereby inducing a novel syndrome of autoimmune autoinflammatory side effects designated as immune related adverse events mainly including rash colitis hepatitis and endocrinopathies. Besides headache dizziness and apathy ataxia tremor paralysis myoclonus cognitive impairment speech disorders and even seizures may occur. After about six months of therapy john tells you that over the past four weeks he has been experiencing increased fatigue weight gain insomnia and constipation. Diarrhea pneumonitis inflammation in the lungs rashes and itchiness problems with some hormone levels kidney infections.

Fatigue weakness nausea confusion headache loss of appetite vision problems fever.